TB-500 (Thymosin Beta-4 Fragment) Research Vial 5mg

TB-500 is a synthetic heptapeptide fragment derived from the naturally occurring 43-amino-acid protein Thymosin Beta-4 (Tβ4). It corresponds specifically to the active actin-binding region (amino acids 17–23) of the parent protein, which is responsible for Tδ’s biological activity in cell migration and cytoskeletal reorganization. As a systemic peptide, TB-500 distributes broadly throughout the body from a single injection site. The primary mechanism involves binding to globular actin (G-actin) and sequestering it, thereby regulating the actin cytoskeleton and promoting cell motility. This actin-binding activity facilitates endothelial cell migration, keratinocyte migration, and angiogenesis—all critical processes in wound healing and tissue repair. TB-500 also exhibits anti-inflammatory effects by downregulating pro-inflammatory cytokines. With 54 PubMed-verified studies, TB-500 has been investigated in preclinical models of soft tissue repair, ligament and tendon recovery, corneal wound healing, and cardiac ischemia. Its systemic distribution profile makes it particularly interesting for researchers studying multi-site or diffuse tissue injury models where local injection is impractical. AllDayGLP supplies TB-500 as a lyophilized powder (5 mg per vial) with ≥98% purity confirmed by independent HPLC analysis. Each batch includes a Certificate of Analysis and is manufactured under controlled laboratory conditions. This product is intended for laboratory research purposes only and is not for human or veterinary use.